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Benzodiazepine remedy needs to be discontinued right away by a gradual and gradual dose reduction routine.[17][seventy five] Tolerance develops into the therapeutic outcomes of benzodiazepines; such as tolerance occurs on the anticonvulsant results and Consequently benzodiazepines are not commonly encouraged for that very long-term management of epilepsy. Dose boosts may possibly get over the consequences of tolerance, but tolerance may perhaps then produce to the upper dose and adverse results could maximize.
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The combination of these two CNS depressants can cause side effects including an unusually very low heartbeat and respiratory difficulties.
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